Wiggins reached 15,000 career points during the contest, while Norman Powell added 25 points. Tyler Herro and Bam Adebayo each scored 13 for Miami, which pulled away with a 39-26 third quarter run.
The Grizzlies, missing Ja Morant, saw GG Jackson score 28 points in the loss. Memphis forward Scotty Pippen Jr. was ejected after a scuffle with Myron Gardner in the fourth quarter.